Description

3-(4-Fluoro-Phenyl)-8-Aza-Bicyclo[3.2.1]Octan-3-Ol is a high-purity, advanced pharmaceutical intermediate featuring a unique bridged bicyclic structure with a fluorinated aromatic moiety. This compound is a critical building block in modern medicinal chemistry, valued for its ability to impart specific conformational and pharmacokinetic properties to target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly within the central nervous system (CNS) and receptor-targeted drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Neurological Drug Discovery: Serves as a building block for potential therapeutics targeting neurological disorders, leveraging its 8-azabicyclo[3.2.1]octane (tropane) core structure.
• Receptor Ligand Synthesis: Employed in the synthesis of selective ligands for neurotransmitter receptors, such as serotonin and dopamine receptors.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and protein functions.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale synthesis during drug development phases.

Basic Information

Product Name	3-(4-Fluoro-Phenyl)-8-Aza-Bicyclo[3.2.1]Octan-3-Ol
CAS No.	1341477-02-8
Molecular Formula	C13H16FNO
Molecular Weight	221.27 g/mol
Synonyms	3-(4-Fluorophenyl)-8-azabicyclo[3.2.1]octan-3-ol; 8-Azabicyclo[3.2.1]octan-3-ol, 3-(4-fluorophenyl)-; 3-(4-Fluorophenyl)tropan-3-ol; 3-(p-Fluorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]octane; 3-Hydroxy-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane; 3-(4-Fluorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]octane; 3-(4-Fluorophenyl)-3-tropanol
EINECS	Contact for details

Quality Control

Our 3-(4-Fluoro-Phenyl)-8-Aza-Bicyclo[3.2.1]Octan-3-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.