Description

6-n-Boc-1-Hydroxy-6-Aza-Spiro[3.4]Octane is a high-value, protected heterocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, particularly for constructing spirocyclic scaffolds found in active pharmaceutical ingredients (APIs). It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of novel spirocyclic compounds in drug discovery and lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the synthesis of linkers and warheads for targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: Employed as a building block for creating potent and selective kinase inhibitors.
• Central Nervous System (CNS) Drug Research: Integral to developing molecules designed to cross the blood-brain barrier for neurological disorders.
• Peptidomimetic Chemistry: Facilitates the creation of conformationally restricted peptide analogs with enhanced metabolic stability.
• Chemical Biology Probe Development: Serves as a scaffold for developing tool compounds to study biological pathways.
• Process Chemistry & Scale-Up: Used in the development of robust, scalable synthetic routes for candidate drugs.

Basic Information

Product Name	6-n-Boc-1-Hydroxy-6-Aza-Spiro[3.4]Octane
CAS No.	1341039-44-8
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	1-Hydroxy-6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[3.4]octane; tert-Butyl 1-hydroxy-6-azaspiro[3.4]octane-6-carboxylate; 6-Boc-1-hydroxy-6-azaspiro[3.4]octane; 6-(tert-Butoxycarbonyl)-1-hydroxy-6-azaspiro[3.4]octane; 6-Azaspiro[3.4]octane-6-carboxylic acid, 1-hydroxy-, 1,1-dimethylethyl ester; Boc-protected 6-azaspiro[3.4]octan-1-ol; 6-n-Boc-1-OH-6-Aza-Spiro[3.4]Octane
EINECS	Contact for details

Quality Control

Our 6-n-Boc-1-Hydroxy-6-Aza-Spiro[3.4]Octane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity confirmation suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept under an inert atmosphere for long-term storage to maintain optimal quality. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.