Description

tert-Butyl 7-(Hydroxymethyl)-2-Azaspiro[4.4]Nonane-2-Carboxylate is a high-value, protected spirocyclic amino acid derivative that serves as a critical advanced pharmaceutical intermediate (API). Its unique spiro[4.4]nonane scaffold and orthogonal protecting groups make it an essential building block for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams developing novel therapeutics, particularly in the areas of neurology and metabolic diseases.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates targeting G-protein-coupled receptors (GPCRs).
• Peptidomimetic Research: Used to introduce conformationally constrained, spirocyclic motifs into peptide backbones to enhance metabolic stability and binding affinity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Building block for creating tool compounds to study enzyme function and cellular pathways.
• Asymmetric Synthesis: Chiral template for the construction of enantiomerically pure compounds in medicinal chemistry campaigns.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials under GMP guidelines.

Basic Information

Product Name	tert-Butyl 7-(Hydroxymethyl)-2-Azaspiro[4.4]Nonane-2-Carboxylate
CAS No.	1341038-97-8
Molecular Formula	C14H25NO3
Molecular Weight	255.35 g/mol
Synonyms	2-Azaspiro[4.4]nonane-2-carboxylic acid, 7-(hydroxymethyl)-, 1,1-dimethylethyl ester; 7-(Hydroxymethyl)-2-azaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 7-(hydroxymethyl)-2-azaspiro[4.4]nonane-2-carboxylate; Boc-7-(hydroxymethyl)-2-azaspiro[4.4]nonane; (7-Hydroxymethyl-2-azaspiro[4.4]non-2-yl)-carbamic acid tert-butyl ester; Protected Spirocyclic β-Amino Ester; Spiro[4.4]nonane amino acid derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-(Hydroxymethyl)-2-Azaspiro[4.4]Nonane-2-Carboxylate is manufactured under strict quality management systems. We provide material with typical purity of ≥97% (HPLC), suitable for advanced research and pre-clinical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to meet the exacting standards of pharmaceutical R&D, and custom synthesis to higher purity grades (≥98%, ≥99%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Allow the sealed container to equilibrate to room temperature before use to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.