Description

5'-Bromo-1',2'-Dihydrospiro[Oxane-4,3'-Pyrrolo[2,3-B]Pyridine]-2'-One is a high-value, spirocyclic heterocyclic compound featuring a fused pyrrolopyridine-oxane structure, serving as a critical synthetic intermediate in advanced pharmaceutical research. Its core value lies in its unique molecular architecture, which provides a versatile scaffold for constructing complex molecules targeting a range of biological pathways. This compound is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold in hit-to-lead and lead optimization programs to explore structure-activity relationships (SAR).
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study enzyme function and cellular signaling pathways.
• Organic Synthesis: A valuable starting material for constructing complex, spirocyclic and fused heterocyclic systems in academic and industrial research.
• Preclinical Development: Supports the synthesis of compounds for in vitro and in vivo pharmacological and toxicological evaluation.

Basic Information

Product Name	5'-Bromo-1',2'-Dihydrospiro[Oxane-4,3'-Pyrrolo[2,3-B]Pyridine]-2'-One
CAS No.	1341038-90-1
Molecular Formula	C11H11BrN2O2
Molecular Weight	283.12 g/mol
Synonyms	5'-Bromo-1',2'-dihydrospiro[oxane-4,3'-pyrrolo[2,3-b]pyridin]-2'-one; Spiro[oxane-4,3'-pyrrolo[2,3-b]pyridine]-2'-one, 5'-bromo-1',2'-dihydro-; 5'-Bromospiro[oxane-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 1341038-90-1; 5-Bromo-1,2-dihydrospiro[oxane-4,3-pyrrolo[2,3-b]pyridin]-2-one; 5'-Bromo-1',2'-dihydro-2'H-spiro[oxane-4,3'-pyrrolo[2,3-b]pyridin]-2'-one
EINECS	Contact for details

Quality Control

Our 5'-Bromo-1',2'-Dihydrospiro[Oxane-4,3'-Pyrrolo[2,3-B]Pyridine]-2'-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.