Description

Racemic-(1R,2S)-Ethyl 2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indoline scaffold. This compound is of significant commercial interest for its role as a key building block in the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of drug candidates with spirocyclic or indoline-based architectures.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Development: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: The racemic mixture provides a starting point for chiral resolution studies or the development of asymmetric catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for investigating biological pathways and target engagement.

Basic Information

Product Name	Racemic-(1R,2S)-Ethyl 2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carboxylate
CAS No.	1341038-75-2
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	Ethyl 2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylate; (±)-Ethyl 2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylate; 1'H-Spiro[cyclopropane-1,3'-indole]-2'(2'H)-one, 2-(ethoxycarbonyl)-, (1'R,2S)-rel-; Spiro[cyclopropane-1,3'-indoline]-2'-one, 2-(ethoxycarbonyl)-; 1341038-75-2; Ethyl 2'-oxo-1'H-spiro[cyclopropane-1,3'-indole]-2-carboxylate
EINECS	Contact for details

Quality Control

Our Racemic-(1R,2S)-Ethyl 2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (IR, NMR), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.