Description

8-Fluoro-1,3,4,5-Tetrahydrobenzo-[B]-1,6-Naphthyridin-10(2H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure incorporating a fluorine atom. This compound is of significant value in modern medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• API Development: A key scaffold for the development of potential Active Pharmaceutical Ingredients (APIs) in preclinical and clinical research stages.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and fluorine-based bioisosterism.

Basic Information

Product Name	8-Fluoro-1,3,4,5-Tetrahydrobenzo-[B]-1,6-Naphthyridin-10(2H)-One
CAS No.	1338652-61-1
Molecular Formula	C₁₄H₁₃FN₂O
Molecular Weight	244.27 g/mol
Synonyms	8-Fluoro-2,3,4,5-tetrahydro-1H-benzo[b][1,6]naphthyridin-10(2H)-one; 8-Fluoro-1,3,4,5-tetrahydro-2H-benzo[b][1,6]naphthyridin-10-one; 8-Fluoro-2,3,4,5-tetrahydro-1H-1,6-naphthyridin-10-one; 1338652-61-1; Benzo[b][1,6]naphthyridin-10(2H)-one, 8-fluoro-1,3,4,5-tetrahydro-; 8-Fluoro-1,2,3,4,5,10-hexahydrobenzo[b][1,6]naphthyridin-10-one
EINECS	Contact for details

Quality Control

Our 8-Fluoro-1,3,4,5-Tetrahydrobenzo-[B]-1,6-Naphthyridin-10(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.