Description

Tri(2-Fmoc-Aminoethyl) Amine is a specialized, multifunctional amine derivative featuring three Fmoc-protected aminoethyl arms. This compound is a critical building block in solid-phase peptide synthesis (SPPS) and other advanced organic synthesis applications, serving as a versatile scaffold or linker. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for constructing complex molecular architectures, such as dendrimers, branched peptides, and functionalized surfaces.

Application

• Solid-Phase Peptide Synthesis (SPPS): Acts as a trifunctional core or branching unit for the synthesis of complex, multi-armed peptide structures.
• Dendrimer Synthesis: Serves as a key precursor or core molecule for constructing polyamidoamine (PAMAM)-type or peptide-based dendrimers.
• Bioconjugation and Linker Chemistry: Used to create heterobifunctional or trifunctional cross-linkers for attaching biomolecules, dyes, or drugs to surfaces or other molecules.
• Material Science: Employed in the surface functionalization of nanoparticles, resins, and other materials to introduce multiple, orthogonally protected amine handles.
• Combinatorial Chemistry: Utilized as a scaffold in library synthesis to generate diverse compound collections with multiple points of diversification.
• Protecting Group Strategy: The Fmoc groups allow for sequential, controlled deprotection, enabling precise stepwise synthesis in multi-step reactions.

Basic Information

Product Name	Tri(2-Fmoc-Aminoethyl) Amine
CAS No.	1338643-94-9
Molecular Formula	C54H51N7O6
Molecular Weight	893.99 g/mol
Synonyms	Tris(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)amine; N,N-Bis(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethanamine; Tris(2-(Fmoc-amino)ethyl)amine; Fmoc-Tris(aminoethyl)amine; Fmoc3-Tren; 1,1',1''-Nitrilotris(2-(Fmoc-amino)ethane); N,N-Bis(2-(Fmoc-amino)ethyl)-Fmoc-aminoethylamine
EINECS	Contact for details

Quality Control

Our Tri(2-Fmoc-Aminoethyl) Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.