Description

(S)-2-Amino-6-(3-(3-(3-Methyl-3H-Diazirin-3-Yl)Propyl)Ureido)Hexanoic Acid is a specialized, high-purity amino acid derivative featuring a photoactivatable diazirine group. This compound matters as a critical crosslinking reagent in chemical biology and proteomics research, enabling the covalent capture and identification of transient biomolecular interactions. It is primarily needed by pharmaceutical R&D teams, academic research laboratories, and biotech companies focused on target identification, drug discovery, and structural biology studies.

Application

• Photoaffinity Labeling (PAL): A key reagent for crosslinking small molecule probes, peptides, or proteins to their biological targets upon UV light activation for interaction mapping.
• Chemical Proteomics: Used to synthesize activity-based probes (ABPs) for profiling enzyme families and identifying drug targets in complex biological systems.
• Bioconjugation & Linker Chemistry: Serves as a heterobifunctional linker, connecting biomolecules via its amino and carboxylic acid functional groups while incorporating a photoreactive handle.
• Structural Biology Studies: Facilitates the study of protein-protein and protein-ligand interaction sites by introducing a covalent crosslink for subsequent analysis via mass spectrometry.
• Drug Discovery Platforms: Integral to developing novel screening assays that capture low-affinity or transient binding events critical for early-stage drug development.
• Material Science Functionalization: Can be used to modify surfaces or polymers with photoreactive groups for creating bioactive materials or biosensors.

Basic Information

Product Name	(S)-2-Amino-6-(3-(3-(3-Methyl-3H-Diazirin-3-Yl)Propyl)Ureido)Hexanoic Acid
CAS No.	1337883-32-5
Molecular Formula	C14H26N6O3
Molecular Weight	326.40 g/mol
Synonyms	L-Lysine derivative with diazirine; 6-[(3-(3-(3-Methyl-3H-diazirin-3-yl)propyl)ureido)]-L-norleucine; Photo-Leucine analog; Diazirine-L-Lysine; Photoactivatable crosslinker; PAL reagent; (S)-2,6-Diaminohexanoic acid diazirine urea derivative; 3-[3-(3-Methyldiazirin-3-yl)propyl]-1-[5-[(1S)-1-amino-1-carboxyethyl]pentyl]urea
EINECS	Contact for details

Quality Control

Our production of (S)-2-Amino-6-(3-(3-(3-Methyl-3H-Diazirin-3-Yl)Propyl)Ureido)Hexanoic Acid adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and support your critical research outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is strictly light-sensitive and hygroscopic; therefore, vials must be kept sealed in opaque containers with desiccant and only handled under controlled conditions to prevent decomposition and moisture uptake. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity (HPLC)	≥ 98% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.