Description

Chloro(2-{Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphino}-3,6-Dimethoxy-2′,4′,6′-Triisopropyl-1,1′-Biphenyl)Gold(I) is a highly specialized, air-stable gold(I) complex featuring a sophisticated, electron-rich phosphine ligand. This compound matters as a premier catalyst for challenging cross-coupling and cyclization reactions, offering superior selectivity and activity under mild conditions. It is essential for researchers and process chemists in pharmaceutical development, advanced materials science, and fine chemical synthesis who require high-performance, reliable catalytic systems.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for constructing complex carbon-heteroatom and carbon-carbon bonds in active pharmaceutical ingredient (API) development.
• Asymmetric Catalysis: Enables enantioselective transformations for the production of chiral molecules in high optical purity.
• Fine Chemical Manufacturing: Used in the synthesis of high-value specialty chemicals, fragrances, and agrochemical intermediates.
• Materials Science Research: Facilitates the polymerization and functionalization of novel organic electronic materials and polymers.
• Cross-Coupling Reactions: Highly effective for Buchwald-Hartwig amination, Suzuki-Miyaura, and related C-N, C-O, and C-C bond-forming reactions.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new reaction pathways in both academic and industrial laboratories.

Basic Information

Item	Details
Product Name	Chloro(2-{Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphino}-3,6-Dimethoxy-2′,4′,6′-Triisopropyl-1,1′-Biphenyl)Gold(I)
CAS No.	1334547-76-0
Molecular Formula	C52H48AuClF12O2P
Molecular Weight	1241.31 g/mol
Synonyms	Chloro[2-[bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-3,6-dimethoxy-2',4',6'-triisopropyl[1,1'-biphenyl]-2-yl]gold; (2-Di(3,5-bis(trifluoromethyl)phenyl)phosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)gold(I) chloride; BrettPhos Gold(I) Chloride; Au(I)-BrettPhos Chloride Complex; Gold(I) BrettPhos Chloride; Chloro(gold) BrettPhos complex; [AuCl(BrettPhos)]
EINECS	Contact for details

Quality Control

Every batch of our gold(I) catalyst is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive catalytic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by NMR and HPLC is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments for pharmaceutical and fine chemical customers.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Gold (Au) Content	15.5 - 16.2 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.