Description

1,6-Diazaspiro[3.5]Nonane-6-Carboxylic Acid, Phenylmethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic diaza structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate complex nitrogen-containing heterocycles into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic scaffold.
• Protease Inhibitor Development: The diazaspiro core is a privileged structure in the design of inhibitors for various enzymes, including proteases.
• Ligand Synthesis for Catalysis: Can be utilized to develop novel chiral or bidentate ligands for asymmetric synthesis and transition metal catalysis.
• Agrochemical Active Ingredient Synthesis: Intermediate in the research and production of advanced crop protection agents with new modes of action.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular tools to study biological pathways and protein function.

Basic Information

Product Name	1,6-Diazaspiro[3.5]Nonane-6-Carboxylic Acid, Phenylmethyl Ester
CAS No.	1334499-75-0
Molecular Formula	C15H18N2O2
Molecular Weight	258.32 g/mol
Synonyms	Benzyl 1,6-diazaspiro[3.5]nonane-6-carboxylate; 6-(Benzyloxycarbonyl)-1,6-diazaspiro[3.5]nonane; 1,6-Diazaspiro[3.5]nonane-6-carboxylic acid benzyl ester; Spiro[3.5]nonane-6-carboxylic acid, 1,6-diaza-, phenylmethyl ester; 6-Cbz-1,6-diazaspiro[3.5]nonane; 1,6-Diazaspiro[3.5]nonan-6-ylcarboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our production of 1,6-Diazaspiro[3.5]Nonane-6-Carboxylic Acid, Phenylmethyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal quality standards and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.