Description

3-Bromo-4-Chloroquinoline-8-Carbonitrile is a high-purity, multi-halogenated quinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which provides versatile reactive sites for constructing complex nitrogen-containing heterocycles essential for pharmaceutical and agrochemical discovery. This compound is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel quinoline-based drug candidates, particularly in oncology and anti-infective research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides that leverage the quinoline core for enhanced bioactivity.
• Material Science Precursor: Serves as a starting material for creating organic semiconductors, light-emitting diodes (OLEDs), and other functional organic electronic materials.
• Chemical Biology Probe Development: Utilized in medicinal chemistry to create molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital intermediate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.
• Academic & Institutional Research: Employed in university and government laboratories for fundamental research in heterocyclic chemistry and reaction methodology development.

Basic Information

Product Name	3-Bromo-4-Chloroquinoline-8-Carbonitrile
CAS No.	1334499-67-0
Molecular Formula	C10H4BrClN2
Molecular Weight	267.51 g/mol
Synonyms	8-Cyano-3-bromo-4-chloroquinoline; 4-Chloro-3-bromoquinoline-8-carbonitrile; 3-Bromo-4-chloro-8-cyanoquinoline; Quinoline-8-carbonitrile, 3-bromo-4-chloro-; 1334499-67-0; BRN 12506617
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-Chloroquinoline-8-Carbonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our products are supported by comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, GC, NMR, and mass spectrometry. We are committed to meeting the stringent requirements of research and development, and specifications can be aligned with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.