Description

4-Benzyl-3,3-Difluoropiperidine Hydrochloride is a high-purity, fluorinated piperidine derivative supplied as a hydrochloride salt, offering enhanced stability and handling properties. This compound serves as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis, particularly for introducing a difluorinated piperidine scaffold. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Building Block for Medicinal Chemistry: Used to construct complex molecules in structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Research: Serves as a precursor in the synthesis of novel pesticides and herbicides, leveraging the biological activity of the fluorinated piperidine moiety.
• Chemical Biology Probe Development: Employed in the creation of tool compounds and probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for the cGMP and non-GMP production of bespoke chemicals for client-specific projects.

Basic Information

Product Name	4-Benzyl-3,3-Difluoropiperidine Hydrochloride
CAS No.	1334415-44-9
Molecular Formula	C12H15F2N·HCl
Molecular Weight	247.71 g/mol
Synonyms	3,3-Difluoro-4-benzylpiperidine hydrochloride; 4-Benzyl-3,3-difluoropiperidine HCl; 3,3-Difluoro-4-(phenylmethyl)piperidine hydrochloride; 1-(Phenylmethyl)-3,3-difluoropiperidin-4-amine hydrochloride (tautomeric form); Piperidine, 4-(phenylmethyl)-3,3-difluoro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Benzyl-3,3-Difluoropiperidine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with material suitable for research use and can provide material manufactured under GMP-like conditions for advanced non-clinical studies upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.