Description

3-Bromo-4-((tert-Butoxycarbonyl)Methyl)Benzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its brominated benzoic acid core and tert-butyloxycarbonyl (Boc) protecting group. This compound is essential for synthetic chemists requiring a versatile building block with orthogonal reactivity for constructing complex molecules. It is primarily utilized in research and development for the synthesis of active pharmaceutical ingredients (APIs) and novel organic compounds, serving the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Organic Synthesis Reagent: Used in coupling reactions, such as Suzuki or Buchwald-Hartwig amination, due to the reactive bromine substituent.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) group provides a stable, acid-labile protecting group for amines in peptide and heterocycle synthesis.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed transformations.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Used in the synthesis of organic semiconductors and functional polymers.

Basic Information

Product Name	3-Bromo-4-((tert-Butoxycarbonyl)Methyl)Benzoic Acid
CAS No.	1333400-84-2
Molecular Formula	C13H15BrO4
Molecular Weight	315.16 g/mol
Synonyms	3-Bromo-4-[(tert-butoxycarbonyl)methyl]benzoic acid; 4-(2-Bromo-4-carboxyphenyl)-2-methyl-2-propanoic acid tert-butyl ester; Benzoic acid, 3-bromo-4-[(1,1-dimethylethoxy)carbonyl]methyl]-; 3-Bromo-4-(Boc-methyl)benzoic acid; 3-Bromo-4-(tert-butoxycarbonylmethyl)benzoic acid; 2-Bromo-4-(2-tert-butoxy-2-oxoethyl)benzoic acid; (3-Bromo-4-carboxyphenyl)acetic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-4-((tert-Butoxycarbonyl)Methyl)Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality system is designed to meet the exacting standards required for pharmaceutical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.