Description

3-(4-Fluorophenyl)Oxetan-3-Amine Hydrochloride is a high-purity, pharmaceutically relevant building block offered as a hydrochloride salt for enhanced stability and handling. This compound is a critical intermediate in modern medicinal chemistry, particularly valued for the oxetane ring, a bioisostere used to fine-tune the physicochemical properties of drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, including kinase inhibitors and central nervous system (CNS) active compounds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Kinase Inhibitor Synthesis: Serves as a core scaffold or side-chain component in the synthesis of targeted kinase inhibitors for oncology.
• CNS Drug Discovery: Employed in the synthesis of compounds targeting neurological disorders due to the favorable properties of the oxetane moiety.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Supplied for route scouting and optimization during the transition from laboratory to pilot-scale synthesis.

Basic Information

Product Name	3-(4-Fluorophenyl)Oxetan-3-Amine Hydrochloride
CAS No.	1332839-79-8
Molecular Formula	C9H11ClFNO
Molecular Weight	203.64 g/mol
Synonyms	3-Amino-3-(4-fluorophenyl)oxetane hydrochloride; 3-(4-Fluorophenyl)-3-oxetanamine hydrochloride; 3-(p-Fluorophenyl)oxetan-3-amine HCl; 1-(4-Fluorophenyl)-1-oxetan-3-ylamine hydrochloride; 3-(4-Fluorophenyl)azetidin-3-ol hydrochloride (incorrect but common misnomer); 4-Fluoro-α-(3-oxetanyl)benzenemethanamine hydrochloride; Oxetan-3-amine, 3-(4-fluorophenyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)Oxetan-3-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.