Description

4-Methyl-1,2,3,4-tetrahydroquinoline-8-carboxylic acid is a high-purity, functionalized tetrahydroquinoline derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in its fused bicyclic structure and the presence of both a carboxylic acid group and a saturated nitrogen-containing ring, making it a versatile building block for constructing complex molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) or possessing anti-inflammatory properties.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the quinoline scaffold's bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science: A building block for organic semiconductors, dyes, and photoactive materials due to its conjugated system.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.
• Academic & Contract Research: Employed in fundamental organic chemistry research and by CROs (Contract Research Organizations) for custom synthesis projects.

Basic Information

Product Name	4-Methyl-1,2,3,4-tetrahydroquinoline-8-carboxylic Acid
CAS No.	1332627-31-2
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	8-Carboxy-4-methyl-1,2,3,4-tetrahydroquinoline; 4-Methyl-1,2,3,4-tetrahydroquinoline-8-carboxylic acid; 1,2,3,4-Tetrahydro-4-methyl-8-quinolinecarboxylic acid; 4-Methyl-5,6,7,8-tetrahydroquinoline-2-carboxylic acid (tautomeric form); 4-Methyl-THQ-8-COOH; 4-Me-THQ-8-COOH; 4-Methyl-1,2,3,4-tetrahydro-8-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Methyl-1,2,3,4-tetrahydroquinoline-8-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing the exact specifications and test results. Our quality commitment supports applications requiring high standards, such as pharmaceutical R&D and advanced material synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.