Description

3-Quinolinecarboxylic Acid, 7-[(3R,4R)-3-Amino-4-(Chloromethyl)-1-Pyrrolidinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-4-Oxo-, Rel- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key chiral building block in the synthesis of novel, potent antibacterial agents, particularly within the fluoroquinolone class. It is essential for pharmaceutical R&D laboratories and manufacturing facilities focused on developing next-generation antibiotics. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and traceability.

Application

• Pharmaceutical Intermediate: Critical chiral synthon for the synthesis of advanced fluoroquinolone antibiotics.
• Antibacterial Drug Development: Used in R&D for creating new antibacterial agents targeting resistant bacterial strains.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a key precursor in the multi-step synthesis of complex API molecules.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production from laboratory to pilot and commercial scale.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Academic & Contract Research: Vital for medicinal chemistry research in academic institutions and CROs (Contract Research Organizations) exploring new antimicrobial therapies.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[(3R,4R)-3-Amino-4-(Chloromethyl)-1-Pyrrolidinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-4-Oxo-, Rel-
CAS No.	1332608-89-5
Molecular Formula	C20H23ClFN3O4
Molecular Weight	423.87 g/mol
Synonyms	(3R,4R)-7-(3-Amino-4-(chloromethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Rel-(3R,4R)-Delafloxacin Intermediate; Delafloxacin Carboxylic Acid Derivative; (R,R)-Delafloxacin Quinoline Intermediate; 7-[(3R,4R)-3-Amino-4-(Chloromethyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; ABT-492 Intermediate (related analog); WCK 771 Intermediate (related analog)
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced and tested under a strict quality management system. Our rigorous quality testing ensures compliance with the high-purity standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, chiral purity, and impurity profiles as determined by HPLC, NMR, and other analytical techniques. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3R,4R)-isomer
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.