Description

6-Aza-Spiro[2.5]Octane-1-Carboxylic Acid is a high-value, spirocyclic building block featuring a constrained bicyclic structure with a carboxylic acid functional group. This unique architecture makes it a critical intermediate for medicinal chemistry research, enabling the synthesis of novel compounds with potential therapeutic applications. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used to introduce conformational rigidity and explore structure-activity relationships (SAR) in lead optimization programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized to create specialized molecular tools for studying biological pathways and protein function.
• Agrochemical Research: Investigated as an intermediate for developing new crop protection agents with novel modes of action.
• Academic & Contract Research: Employed in university and CRO settings for exploratory synthetic chemistry and methodology development.

Basic Information

Product Name	6-Aza-Spiro[2.5]Octane-1-Carboxylic Acid
CAS No.	1332530-45-6
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	6-Azaspiro[2.5]octane-1-carboxylic acid; 1-Carboxy-6-azaspiro[2.5]octane; 6-Aza-spiro[2.5]octane-1-carboxylic acid; Azaspirooctanecarboxylic acid; 1-(Carboxy)-6-azaspiro[2.5]octane; 6-Aza-1-carboxyspiro[2.5]octane; 1332530-45-6
EINECS	Contact for details

Quality Control

Our 6-Aza-Spiro[2.5]Octane-1-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development projects with custom synthesis and analytical method development to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.