Description

9-Methyl-1-Oxa-9-Azaspiro[5.5]Undec-4-Yl Methanesulfonate Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of novel drug candidates, especially those targeting neurological pathways.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the complex multi-step synthesis of proprietary APIs for clinical and commercial manufacturing.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development & Scale-Up: Employed in route scouting, process optimization, and kilogram-to-ton scale production under cGMP conditions.
• Reference Standard: Used as an analytical standard for quality control and method validation in regulatory filings.

Basic Information

Product Name	9-Methyl-1-Oxa-9-Azaspiro[5.5]Undec-4-Yl Methanesulfonate Hydrochloride
CAS No.	1332529-85-7
Molecular Formula	C12H23NO5S • HCl
Molecular Weight	337.84 g/mol (as hydrochloride salt)
Synonyms	9-Methyl-1-oxa-9-azaspiro[5.5]undecan-4-yl methanesulfonate hydrochloride; 1-Oxa-9-azaspiro[5.5]undecane, 9-methyl-4-(methylsulfonyloxy)-, hydrochloride; 9-Methyl-4-((methylsulfonyl)oxy)-1-oxa-9-azaspiro[5.5]undecane hydrochloride; Methanesulfonic acid, 9-methyl-1-oxa-9-azaspiro[5.5]undec-4-yl ester, hydrochloride
EINECS	Contact for details

Quality Control

Our 9-Methyl-1-Oxa-9-Azaspiro[5.5]Undec-4-Yl Methanesulfonate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.