Description

5,5-Difluoro-2-Azaspiro[3.3]Heptane Trifluoroacetic Acid is a high-value, multifunctional spirocyclic building block featuring a unique nitrogen-containing heterocycle and fluorine substituents. This compound matters for its critical role in modern medicinal chemistry, where its rigid scaffold and fluorine atoms are leveraged to modulate the physicochemical and pharmacokinetic properties of drug candidates. Pharmaceutical researchers and agrochemical developers need this advanced intermediate for the synthesis of novel active ingredients, particularly in the areas of small molecule therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of novel polymers and functional materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Fragment-Based Drug Discovery (FBDD): Its rigid, three-dimensional structure makes it a valuable fragment for screening against challenging biological targets.

Basic Information

Product Name	5,5-Difluoro-2-Azaspiro[3.3]Heptane Trifluoroacetic Acid
CAS No.	1330765-36-0
Molecular Formula	C8H9F5NO2
Molecular Weight	255.16 g/mol
Synonyms	5,5-Difluoro-2-azaspiro[3.3]heptane-2-carboxylic acid, 2,2,2-trifluoroacetate; 5,5-Difluoro-2-azaspiro[3.3]heptane TFA salt; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 5,5-difluoro-, 2,2,2-trifluoroacetate (1:1); 5,5-Difluoro-2-azaspiro[3.3]heptane trifluoroacetate; 1330765-36-0; 5,5-Difluoro-2-azaspiro[3.3]heptane-2-carboxylic acid trifluoroacetic acid salt
EINECS	Contact for details

Quality Control

Our 5,5-Difluoro-2-Azaspiro[3.3]Heptane Trifluoroacetic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of the pharmaceutical and fine chemical industries. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.