Description

tert-Butyl 1-(Benzyloxycarbonylamino)-3-Azabicyclo[3.2.0]Heptane-3-Carboxylate is a sophisticated bicyclic amino acid derivative, serving as a critical advanced pharmaceutical intermediate (API) in modern synthetic chemistry. Its unique fused ring structure makes it a valuable building block for constructing complex molecules with specific three-dimensional architectures. This compound is primarily sought after by pharmaceutical R&D and contract manufacturing organizations (CMOs) engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Key synthon in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Protease Inhibitor Research: Used as a core scaffold in the development of novel protease inhibitors for antiviral and anticancer applications.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for creating stable peptide mimics with enhanced bioavailability.
• Medicinal Chemistry & Drug Discovery: A versatile building block for constructing focused libraries and exploring structure-activity relationships (SAR) in lead optimization.
• Chemical Biology Probes: Utilized in the development of specialized probes for studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Employed in chiral synthesis due to its inherent stereogenic centers, facilitating the production of enantiomerically pure compounds.

Basic Information

Product Name	tert-Butyl 1-(Benzyloxycarbonylamino)-3-Azabicyclo[3.2.0]Heptane-3-Carboxylate
CAS No.	1330763-68-2
Molecular Formula	C19H26N2O4
Molecular Weight	346.42 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-[(1,1-dimethylethoxy)carbonyl]-3-azabicyclo[3.2.0]heptane; 3-Azabicyclo[3.2.0]heptane-3-carboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester; tert-Butyl 1-(Cbz-amino)-3-azabicyclo[3.2.0]heptane-3-carboxylate; 1-N-Cbz-3-N-Boc-3-azabicyclo[3.2.0]heptane; Bicyclic Cbz/Boc-protected amino ester; Z-1-Amino-3-azabicyclo[3.2.0]heptane-3-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 1-(Benzyloxycarbonylamino)-3-Azabicyclo[3.2.0]Heptane-3-Carboxylate adheres to stringent GMP-like guidelines suitable for pharmaceutical intermediate applications. Every batch undergoes comprehensive analytical characterization using HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.