Description

Benzyl 1-Oxo-2,3-Dihydro-1H-Spiro[Isoquinoline-4,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic molecular architecture. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique spirocyclic scaffold.
• API Synthesis: Serves as a crucial building block in multi-step synthesis routes for complex target molecules in preclinical and clinical development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of investigational new drugs.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Benzyl 1-Oxo-2,3-Dihydro-1H-Spiro[Isoquinoline-4,4'-Piperidine]-1'-Carboxylate
CAS No.	1330763-54-6
Molecular Formula	C21H20N2O3
Molecular Weight	348.40 g/mol
Synonyms	Benzyl 1'-carboxylate-1-oxo-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]; 1H-Spiro[isoquinoline-4,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-1-oxo-, phenylmethyl ester; 1-Oxo-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylic acid benzyl ester; Spiro[isoquinoline-4,4'-piperidine] intermediate; CAS 1330763-54-6
EINECS	Contact for details

Quality Control

Our Benzyl 1-Oxo-2,3-Dihydro-1H-Spiro[Isoquinoline-4,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.