Description

2-(2-Boc-5-Oxa-2-Azaspiro[3.4]Octan-7-Yl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially those requiring complex, three-dimensional spirocyclic structures.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linkers and warhead components for targeted protein degradation therapies.
• Peptidomimetic Chemistry: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization during the transition from laboratory-scale discovery to commercial manufacturing.
• Custom Synthesis & Contract Manufacturing: Provided to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-(2-Boc-5-Oxa-2-Azaspiro[3.4]Octan-7-Yl)Acetic Acid
CAS No.	1330763-34-2
Molecular Formula	C13H21NO6
Molecular Weight	287.31 g/mol
Synonyms	2-(2-((tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-7-yl)acetic acid; 7-Carboxymethyl-2-N-Boc-2,5-dioxa-8-azaspiro[3.4]octane; Boc-5-Oxa-2-Azaspiro[3.4]Octane-7-Acetic Acid; (2-Boc-5-oxa-2-azaspiro[3.4]oct-7-yl)acetic acid; tert-Butyl 7-(carboxymethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 1330763-34-2; Spirocyclic Boc-protected amino acid derivative.
EINECS	Contact for details

Quality Control

Our 2-(2-Boc-5-Oxa-2-Azaspiro[3.4]Octan-7-Yl)Acetic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.