Description

tert-Butyl 3-(Iodomethyl)-2-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate is a high-value, multifunctional organic building block featuring a spirocyclic scaffold, an iodine substituent, and a Boc-protected amine. This compound matters for its role as a key synthetic intermediate in the development of complex bioactive molecules, offering versatile sites for further chemical elaboration. It is primarily needed by pharmaceutical and agrochemical research organizations for constructing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides with complex molecular architectures.
• Chemical Biology Probes: Utilized to create labeled compounds or probes for studying biological pathways and target engagement.
• Peptidomimetic Development: The spirocyclic and protected amine structure makes it valuable for designing peptide mimics with enhanced stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 3-(Iodomethyl)-2-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate
CAS No.	1330763-32-0
Molecular Formula	C15H26INO3
Molecular Weight	395.28 g/mol
Synonyms	9-Boc-3-(iodomethyl)-2-oxa-9-azaspiro[5.5]undecane; tert-Butyl 3-(iodomethyl)-2-oxa-9-azaspiro[5.5]undecane-9-carboxylate; 2-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-(iodomethyl)-, 1,1-dimethylethyl ester; Boc-3-iodomethyl-2-oxa-9-azaspiro[5.5]undecane; 1330763-32-0; 3-(Iodomethyl)-2-oxa-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Iodomethyl)-2-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply under more stringent quality protocols, including cGMP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.