Description

8-Chloro-3-Iodo-1H-Quinolin-4-One is a halogenated quinolinone derivative, a versatile and highly functionalized heterocyclic building block. Its unique structure, featuring both chlorine and iodine substituents, makes it a critical intermediate for synthesizing complex molecules in advanced research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the creation of novel active ingredients, as well as by academic and industrial chemists exploring new materials and catalysts.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antimicrobials, and anti-inflammatory agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated quinoline core for bioactivity.
• Organic Synthesis Building Block: Provides a versatile scaffold for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) facilitated by the reactive iodine atom.
• Material Science Research: Investigated as a precursor for organic electronic materials, ligands for metal-organic frameworks (MOFs), or specialty dyes and pigments.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	8-Chloro-3-Iodo-1H-Quinolin-4-One
CAS No.	1330750-92-9
Molecular Formula	C9H5ClINO
Molecular Weight	305.50 g/mol
Synonyms	8-Chloro-3-iodoquinolin-4(1H)-one; 3-Iodo-8-chloro-1H-quinolin-4-one; 4(1H)-Quinolinone, 8-chloro-3-iodo-; 8-Chloro-3-iodo-4-hydroxyquinoline; 8-Chloro-3-iodo-4-quinolone
EINECS	Contact for details

Quality Control

Our 8-Chloro-3-Iodo-1H-Quinolin-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.