Description

(Trans)-4-(4-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid-2Hcl is a high-purity, non-natural amino acid derivative featuring a rigid trans-configured pyrrolidine scaffold substituted with a pyridinyl group, making it a valuable chiral building block for pharmaceutical research and development. Its primary value lies in its role as a key intermediate for synthesizing complex molecules, particularly in the creation of novel drug candidates targeting neurological and metabolic disorders. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities with improved potency and selectivity.
• Peptidomimetics Development: Serves as a constrained, non-proteinogenic amino acid analog for designing novel peptide-like molecules with enhanced metabolic stability.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized as a building block for creating chemical probes to study enzyme function and protein-protein interactions.
• Academic & Contract Research: A key reagent for academic institutions and CROs (Contract Research Organizations) engaged in cutting-edge organic and medicinal chemistry projects.

Basic Information

Product Name	(Trans)-4-(4-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid-2Hcl
CAS No.	1330750-49-6
Molecular Formula	C10H12N2O2 • 2HCl
Molecular Weight	281.14 g/mol (Free base: 192.22)
Synonyms	(3R,4R)-4-(Pyridin-4-yl)pyrrolidine-3-carboxylic acid dihydrochloride; (3R,4R)-4-(4-Pyridyl)-3-pyrrolidinecarboxylic acid dihydrochloride; trans-4-(4-Pyridyl)-3-pyrrolidinecarboxylic acid 2HCl; 4-(4-Pyridinyl)-3-pyrrolidinecarboxylic acid, (3R,4R)-, hydrochloride (1:2); (3R,4R)-4-(4-Pyridinyl)pyrrolidine-3-carboxylic acid hydrochloride; (3R,4R)-4-(Pyridin-4-yl)pyrrolidine-3-carboxylic acid hydrochloride (2:1)
EINECS	Contact for details

Quality Control

Our (Trans)-4-(4-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid-2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.