Description

(3S)-Aminoquinuclidine-D1 Dihydrochloride CAS NO 1329838-74-5 is a deuterated derivative of aminoquinuclidine, a key chiral building block and pharmacophore in medicinal chemistry. This isotopically labeled compound is essential for advanced research and development, particularly in drug metabolism and pharmacokinetic (DMPK) studies, where it serves as an internal standard for mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on neuroscience, cardiovascular, and other therapeutic areas involving nicotinic and muscarinic receptor pathways.

Application

• Internal Standard for LC-MS/MS: Critical for the quantitative bioanalysis of aminoquinuclidine-based drug candidates in biological matrices.
• Metabolite Identification & Tracing: Used in drug metabolism studies (ADME) to track and identify metabolites due to its deuterium label.
• Pharmacokinetic (PK) Research: Enables accurate and reliable measurement of absorption, distribution, and clearance of parent compounds.
• Medicinal Chemistry & SAR Studies: Serves as a chiral scaffold for synthesizing novel analogs to explore structure-activity relationships.
• Neuroscience Research: Investigated for its potential interaction with acetylcholine receptors relevant to cognitive and neurological disorders.
• Reference Standard: Provides a certified reference material for method development, validation, and quality control in analytical laboratories.

Basic Information

Product Name	(3S)-Aminoquinuclidine-D1 Dihydrochloride
CAS No.	1329838-74-5
Molecular Formula	C7H12DCl2N2
Molecular Weight	187.10 g/mol
Synonyms	(3S)-3-Aminoquinuclidine-2,2,3-d3 Dihydrochloride; (3S)-3-Aminoquinuclidine-d1 Dihydrochloride; 3-Aminoquinuclidine-D1 Dihydrochloride; (S)-3-Aminoquinuclidine-D1 Dihydrochloride; 1-Azabicyclo[2.2.2]octan-3-amine-3-d Dihydrochloride; Amino-quinuclidine-D1 Dihydrochloride; Deuterated (3S)-Aminoquinuclidine Dihydrochloride
EINECS	Contact for details

Quality Control

Our (3S)-Aminoquinuclidine-D1 Dihydrochloride is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-content), and impurity profile. We adhere to cGMP principles for research chemicals, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.