Description

n-[3-Fluoro-4-(Trifluoromethyl)Benzyl]Piperidin-4-Amine Dihydrochloride is a high-purity, fluorinated piperidine derivative dihydrochloride salt, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a versatile and reactive scaffold for medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating new small-molecule therapeutics targeting central nervous system (CNS) disorders, inflammation, and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in CNS-targeted therapies and anti-inflammatory agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated aromatic and piperidine amine functionalities.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation pesticides and herbicides, leveraging the trifluoromethyl group for enhanced activity.
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized fine chemicals for client projects.
• Academic Research: Employed in university and institutional labs for fundamental organic synthesis research and the development of new synthetic methodologies.

Basic Information

Product Name	n-[3-Fluoro-4-(Trifluoromethyl)Benzyl]Piperidin-4-Amine Dihydrochloride
CAS No.	1322200-87-2
Molecular Formula	C14H17F4N2•2HCl
Molecular Weight	369.21 g/mol (Free base: 297.30 g/mol)
Synonyms	4-Amino-1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]piperidine dihydrochloride; 1-[(3-Fluoro-4-(trifluoromethyl)phenyl)methyl]piperidin-4-amine dihydrochloride; 4-Piperidinamine, 1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-, dihydrochloride; 3-Fluoro-4-(trifluoromethyl)benzyl piperidin-4-ylamine dihydrochloride; N-((3-Fluoro-4-(trifluoromethyl)phenyl)methyl)piperidin-4-amine dihydrochloride; CAS 1322200-87-2
EINECS	Contact for details

Quality Control

Our n-[3-Fluoro-4-(Trifluoromethyl)Benzyl]Piperidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.