Description

2,5,8,11,14,17,20,23-Octaoxapentacosane, 25-Iodo- is a high-purity, iodinated polyethylene glycol (PEG) derivative, specifically a long-chain PEG iodide. This compound is a valuable synthetic intermediate and functionalization agent, prized for its terminal iodine atom which serves as an excellent leaving group for nucleophilic substitution reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as bioconjugation, polymer modification, and the synthesis of complex organic molecules.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs via nucleophilic displacement of the iodine atom.
• Bioconjugation & PEGylation: Acts as a key reagent for attaching polyethylene glycol (PEG) chains to peptides, proteins, and antibodies to enhance solubility, stability, and circulation time.
• Polymer & Materials Science: Serves as a functional initiator or terminating agent in the synthesis of block copolymers and surface-functionalized nanomaterials.
• Crosslinking Agent: Employed in the creation of hydrogels, polymer networks, and dendrimers due to its bifunctional PEG spacer and reactive iodine terminus.
• Organic Synthesis Building Block: Provides a versatile, long-chain alkylating agent for introducing PEGylated segments into complex molecular architectures.
• Ligand & Probe Synthesis: Utilized in the development of diagnostic agents, imaging probes, and targeted drug delivery systems.

Basic Information

Product Name	2,5,8,11,14,17,20,23-Octaoxapentacosane, 25-Iodo-
CAS No.	1319730-07-8
Molecular Formula	C17H35IO8
Molecular Weight	494.36 g/mol
Synonyms	25-Iodo-2,5,8,11,14,17,20,23-octaoxapentacosane; Iodooctaethylene glycol monomethyl ether; mPEG8-Iodide; Methyl-PEG8-Iodide; Poly(ethylene glycol) methyl ether iodide (n~8); 2-[2-[2-[2-[2-[2-[2-(2-Iodoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl methyl ether; Iodo-PEG8-OMe; PEG-Iodide (MW ~500)
EINECS	Contact for details

Quality Control

Our 2,5,8,11,14,17,20,23-Octaoxapentacosane, 25-Iodo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. For long-term storage, keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.