Description

5-Bromo-2-Methyl-2H-Pyrazolo[3,4-B]Pyridine is a high-purity, heterocyclic brominated building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or charge-transport molecules.
• Chemical Biology: Employed as a probe or labeling agent in biochemical assays due to the reactive bromine handle.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Academic & Contract Research: Essential for methodological studies and custom synthesis projects in university and CRO laboratories.

Basic Information

Product Name	5-Bromo-2-Methyl-2H-Pyrazolo[3,4-B]Pyridine
CAS No.	1316852-65-9
Molecular Formula	C8H6BrN3
Molecular Weight	224.06 g/mol
Synonyms	5-Bromo-2-methyl-2H-pyrazolo[3,4-b]pyridine; 2-Methyl-5-bromo-2H-pyrazolo[3,4-b]pyridine; 5-Bromo-2-methyl-2H-pyrazolo[3,4-b]pyridine; 5-Bromo-2-methylpyrazolo[3,4-b]pyridine; Pyrazolo[3,4-b]pyridine, 5-bromo-2-methyl-; 1316852-65-9 (CAS); 5-Br-2-Me-Pyrazolopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Methyl-2H-Pyrazolo[3,4-B]Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.