Description

[(2R)-4,4-Difluoropyrrolidin-2-Yl]Methanol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its defined stereochemistry and functionalized pyrrolidine core, which is critical for the synthesis of bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on novel drug candidates, including kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted cancer therapies and central nervous system (CNS) drugs.
• Kinase Inhibitor Synthesis: Serves as a critical precursor in the production of potent and selective kinase inhibitors, a major class of oncology therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of novel crop protection agents and pesticides due to its fluorinated heterocyclic structure.
• Chemical Biology & Proteomics: Employed as a tool compound or a building block for chemical probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale manufacturing of clinical trial materials under GMP guidelines.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis services catering to the specific needs of biotechnology and pharmaceutical companies.

Basic Information

Product Name	[(2R)-4,4-Difluoropyrrolidin-2-Yl]Methanol Hydrochloride
CAS No.	1315593-71-5
Molecular Formula	C6H12ClF2NO
Molecular Weight	187.61 g/mol
Synonyms	(2R)-4,4-Difluoro-2-(hydroxymethyl)pyrrolidine hydrochloride; (R)-4,4-Difluoro-2-(hydroxymethyl)pyrrolidine HCl; (2R)-4,4-Difluoropyrrolidine-2-methanol hydrochloride; (R)-4,4-Difluoropyrrolidin-2-ylmethanol hydrochloride; 4,4-Difluoro-D-prolinol hydrochloride; (R)-(-)-4,4-Difluoro-2-pyrrolidinemethanol hydrochloride; 1315593-71-5; (2R)-4,4-Difluoro-2-pyrrolidinemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our [(2R)-4,4-Difluoropyrrolidin-2-Yl]Methanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.