Description

2-Oxa-8-Azaspiro[4.5]Decan-1-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those with spirocyclic or bridged heterocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• API Development: Serves as a precursor in the scalable production route development for potential new active pharmaceutical ingredients.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Academic & Industrial R&D: Fundamental research in organic synthesis methodologies and the exploration of new chemical space for drug discovery.

Basic Information

Product Name	2-Oxa-8-Azaspiro[4.5]Decan-1-One Hydrochloride
CAS No.	1314965-08-6
Molecular Formula	C8H14ClNO2
Molecular Weight	191.66 g/mol
Synonyms	1-Oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride; 8-Azaspiro[4.5]decan-1-one, 2-oxa-, hydrochloride; 2-Oxa-8-azaspiro[4.5]decan-1-one HCl; Spiro[4.5]decan-1-one, 2-oxa-8-aza-, hydrochloride; 1314965-08-6
EINECS	Contact for details

Quality Control

Our 2-Oxa-8-Azaspiro[4.5]Decan-1-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.