Description

5-Amino-Spiro[2.3]Hexane-5-Carboxylic Acid is a specialized spirocyclic amino acid derivative, a high-value building block prized for its unique three-dimensional structure and constrained geometry. This compound is essential for medicinal chemistry research and development, enabling the creation of novel molecular architectures with potentially enhanced biological activity and metabolic stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas like protease inhibitors and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and scaffold hopping to explore new chemical space and improve drug-like properties.
• Protease Inhibitor Development: The constrained spirocyclic structure is valuable for designing potent and selective enzyme inhibitors.
• Peptidomimetics: Serves as a non-natural amino acid analog to create peptide mimics with enhanced stability and bioavailability.
• Chemical Biology Probes: Used in the development of tool compounds for target identification and validation in biological systems.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthesis routes.

Basic Information

Product Name	5-Amino-Spiro[2.3]Hexane-5-Carboxylic Acid
CAS No.	1314939-85-9
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	5-Azaspiro[2.3]hexane-5-carboxylic acid, 5-amino-; 5-Amino-5-carboxyspiro[2.3]hexane; 5-Amino-spiro[2.3]hexane-5-carboxylic acid; 1-Amino-cyclopropane-1-carboxylic acid, spiro-fused; 5-Amino-1-oxaspiro[2.3]hexane-5-carboxylic acid (related structure); Aminospirohexanecarboxylic Acid; ASHC; Spirocyclic β-amino acid
EINECS	Contact for details

Quality Control

Our 5-Amino-Spiro[2.3]Hexane-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with full analytical data are provided to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.