Description

2-Ethynylpyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a reactive alkyne functional group on a pyrrolidine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates through click chemistry and other coupling reactions. It is primarily sought after by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in developing new therapeutic agents, particularly for central nervous system (CNS) and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization studies to introduce the ethynyl moiety for structure-activity relationship (SAR) exploration.
• Click Chemistry Reagent: Serves as a versatile component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and library synthesis.
• Proteolysis-Targeting Chimera (PROTAC) Development: Utilized in constructing linker components for bifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Incorporated into molecular probes for studying biological pathways and target engagement.
• CNS Drug Discovery: Applied in the research of potential therapeutics for neurological disorders due to the pyrrolidine core's relevance to neuropharmacology.

Basic Information

Product Name	2-Ethynylpyrrolidine Hydrochloride
CAS No.	1314937-87-5
Molecular Formula	C6H9N•HCl
Molecular Weight	131.60 g/mol
Synonyms	2-Ethynylpyrrolidine HCl; 1-(2-Propynyl)pyrrolidine Hydrochloride; Pyrrolidine, 2-ethynyl-, hydrochloride; 2-Ethynyl-1-azacyclopentane Hydrochloride; 2-Ethynylpyrrolidinium Chloride
EINECS	Contact for details

Quality Control

Our 2-Ethynylpyrrolidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.