Description

6-(tert-Butoxycarbonyl)-6-Azaspiro[3.4]Octane-8-Carboxylic Acid is a high-value, protected spirocyclic amino acid derivative used as a sophisticated building block in advanced organic synthesis. This compound matters because it provides a rigid, three-dimensional scaffold that is crucial for modulating the physicochemical properties and biological activity of target molecules. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the research and development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Proteolysis Targeting Chimera (PROTAC) Development: Used to construct the linker or ligand components of bifunctional molecules designed for targeted protein degradation.
• Peptidomimetic Chemistry: Incorporates a constrained, spirocyclic structure to replace traditional amino acids, enhancing metabolic stability and receptor selectivity in peptide-based drugs.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study enzyme function and protein-protein interactions.
• Agrochemical Research: Employed in the discovery of new active ingredients with improved efficacy and environmental profiles.
• Material Science: Potential monomer for creating novel polymers with specific structural or functional properties.

Basic Information

Product Name	6-(tert-Butoxycarbonyl)-6-Azaspiro[3.4]Octane-8-Carboxylic Acid
CAS No.	1314388-77-6
Molecular Formula	C15H23NO4
Molecular Weight	281.35 g/mol
Synonyms	6-[(1,1-Dimethylethoxy)carbonyl]-6-azaspiro[3.4]octane-8-carboxylic acid; 6-(Boc)-6-Azaspiro[3.4]octane-8-carboxylic Acid; Boc-6-Azaspiro[3.4]octane-8-carboxylic Acid; tert-Butyl 8-carboxy-6-azaspiro[3.4]octane-6-carboxylate; 6-Azaspiro[3.4]octane-8-carboxylic acid, 6-[(1,1-dimethylethoxy)carbonyl]-; 6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octane-8-carboxylic acid; Spirocyclic Boc-Amino Acid
EINECS	Contact for details

Quality Control

Our 6-(tert-Butoxycarbonyl)-6-Azaspiro[3.4]Octane-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.