Description

(2S)-8-Methyl-8-Aza-Bicyclo[3.2.1]Octan-3-Yl 3-(Methylsulfonyloxy)-2-Phenylpropanoate is a high-purity, advanced pharmaceutical intermediate with a complex stereospecific structure. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting the central nervous system, where precise molecular configuration is paramount for efficacy. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the areas of neurology and psychiatry.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex drug molecules, particularly tropane alkaloid derivatives.
• Neurological & Psychiatric Drug Research: Used in the research and development of new compounds targeting neurotransmitter systems.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale production for new chemical entities (NCEs).
• Asymmetric Synthesis Studies: Valuable for studying and developing new stereoselective synthetic methodologies in organic chemistry.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(2S)-8-Methyl-8-Aza-Bicyclo[3.2.1]Octan-3-Yl 3-(Methylsulfonyloxy)-2-Phenylpropanoate
CAS No.	1313716-46-9
Molecular Formula	C19H27NO5S
Molecular Weight	381.49 g/mol
Synonyms	(2S)-Tropan-3-yl 3-(methylsulfonyloxy)-2-phenylpropanoate; (2S)-3-Tropanyl 3-(mesyloxy)-2-phenylpropionate; (2S)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-(methylsulfonyloxy)-2-phenylpropanoate; (S)-Tropine 3-(methylsulfonyloxy)-2-phenylpropionate; Tropane-3β-yl (2S)-3-(methylsulfonyloxy)-2-phenylpropanoate; 1313716-46-9; Tropane mesylate ester intermediate
EINECS	Contact for details

Quality Control

Our production of (2S)-8-Methyl-8-Aza-Bicyclo[3.2.1]Octan-3-Yl 3-(Methylsulfonyloxy)-2-Phenylpropanoate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques (HPLC, GC, NMR, MS) to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.