Description

tert-Butyl 5,6,7,8-Tetrahydroquinolin-8-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its carbamate-protected amine functionality on a partially saturated quinoline scaffold. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry research and development.
• API Synthesis: Used as a protected amine synthon for constructing complex molecular architectures in the final stages of Active Pharmaceutical Ingredient (API) manufacturing.
• Chemical Research: Employed in academic and industrial laboratories for method development, catalysis studies, and exploring new chemical reactions involving nitrogen heterocycles.
• Process Chemistry: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial production, where consistent quality is paramount.
• Protease Inhibitor Development: Acts as a structural component in the research of compounds designed to modulate enzymatic activity.
• Ligand Synthesis: Provides a framework for creating specialized ligands used in asymmetric catalysis and metal-organic chemistry.

Basic Information

Product Name	tert-Butyl 5,6,7,8-Tetrahydroquinolin-8-Ylcarbamate
CAS No.	1313712-47-8
Molecular Formula	C₁₅H₂₀N₂O₂
Molecular Weight	260.33 g/mol
Synonyms	8-(((tert-Butoxy)carbonyl)amino)-5,6,7,8-tetrahydroquinoline; tert-Butyl N-(5,6,7,8-tetrahydroquinolin-8-yl)carbamate; 8-Boc-amino-5,6,7,8-tetrahydroquinoline; 5,6,7,8-Tetrahydroquinolin-8-yl-carbamic acid tert-butyl ester; Boc-8-amino-5,6,7,8-tetrahydroquinoline; 8-N-Boc-5,6,7,8-tetrahydroquinoline; 8-Amino-5,6,7,8-tetrahydroquinoline tert-butyl carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5,6,7,8-Tetrahydroquinolin-8-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.