Description

3-Nitro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrazole is a specialized, high-value pyrazole derivative featuring a silyl-protected hydroxymethyl group. This compound is a critical protected synthetic intermediate designed for advanced organic synthesis, particularly in the construction of complex heterocyclic molecules. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs) and novel agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other heterocycle-dependent biological pathways.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the pyrazole core is a common bioactive motif.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialized polymers and advanced organic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in heterocyclic and organosilicon chemistry.
• Custom Synthesis: A starting material for the tailored production of complex, multi-functional molecules for specific client projects.

Basic Information

Product Name	3-Nitro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrazole
CAS No.	1313520-83-0
Molecular Formula	C9H19N3O3Si
Molecular Weight	245.35 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-3-nitropyrazole; 3-Nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole; 1H-Pyrazole, 3-nitro-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 3-Nitro-1-SEM-pyrazole; SEM-Protected 3-Nitropyrazole; 3-Nitropyrazole SEM ether
EINECS	Contact for details

Quality Control

Every batch of 3-Nitro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrazole is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical synthesis workflows. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.