Description

Bzl-D-Gln-Ome Hcl CAS NO 1313054-29-3 is a protected D-glutamine derivative, specifically the benzyl ester hydrochloride salt, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a stereochemically pure, readily incorporable glutamine residue for constructing complex peptides and peptidomimetics, which are essential in pharmaceutical research and development. This high-purity intermediate is indispensable for medicinal chemists and researchers in the pharmaceutical, biotechnology, and agrochemical industries focused on developing novel therapeutic agents, enzyme inhibitors, and bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop novel enzyme inhibitors and receptor ligands.
• Bioconjugation: Serves as a modified amino acid for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Agrochemical Development: Building block for synthesizing bioactive peptides with potential pesticidal or plant growth regulatory activity.
• Academic Research: Essential reagent in university and institutional labs for studying peptide structure, function, and synthesis methodologies.
• Custom Peptide Synthesis: Used by CROs and CDMOs for the custom manufacturing of non-standard peptides containing D-glutamine.

Basic Information

Item	Detail
Product Name	Bzl-D-Gln-Ome Hcl
CAS No.	1313054-29-3
Molecular Formula	C13H19ClN2O4
Molecular Weight	302.75 g/mol
Synonyms	H-D-Gln-OBzl HCl; D-Glutamine, N2-benzyloxycarbonyl-, benzyl ester, hydrochloride; Z-D-Gln-OBzl HCl; N-Carbobenzoxy-D-glutamine benzyl ester hydrochloride; Cbz-D-Glutamine benzyl ester hydrochloride; (R)-2-((Benzyloxycarbonyl)amino)-5-(benzyloxy)-5-oxopentanoic acid hydrochloride; Benzyl N-[(1R)-4-(benzyloxy)-1-(hydroxycarbonyl)-4-oxobutyl]carbamate hydrochloride
EINECS	Contact for details

Quality Control

Our Bzl-D-Gln-Ome Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet stringent customer specifications. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Solubility	Soluble in DMF, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.