Description

4,4,4-Trifluorobutane-1,3-Diamine Dihydrochloride is a high-purity, fluorinated diamine building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group, enabling the development of novel compounds with enhanced metabolic stability and bioavailability. This material is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), specialty ligands, and complex fluorinated molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging the trifluoromethyl group to modulate lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the introduction of fluorine atoms can enhance biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and catalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Peptidomimetics & Bio-conjugation: The diamine functionality allows for incorporation into peptide backbones or as a linker for bio-conjugation strategies in medicinal chemistry and biotech research.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, resins, and specialty coatings that require specific thermal and chemical resistance properties.
• Chemical Biology Probes: Useful for creating fluorinated probes and tags for imaging, diagnostics, and studying biological mechanisms.

Basic Information

Product Name	4,4,4-Trifluorobutane-1,3-Diamine Dihydrochloride
CAS No.	1311316-33-2
Molecular Formula	C4H10Cl2F3N2
Molecular Weight	223.04 g/mol
Synonyms	1,3-Diamino-4,4,4-trifluorobutane Dihydrochloride; 4,4,4-Trifluoro-1,3-butanediamine Dihydrochloride; 4,4,4-Trifluorobutane-1,3-diamine 2HCl; 3-Amino-4,4,4-trifluorobutylamine Dihydrochloride; 4,4,4-Trifluoro-1,3-diaminobutane Dihydrochloride; 1,3-Butanediamine, 4,4,4-trifluoro-, Dihydrochloride; TFBD Dihydrochloride
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorobutane-1,3-Diamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.