Description

4-Chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid is a high-value, multi-functional pyrazole derivative serving as a critical synthetic intermediate. Its unique structure, featuring both chloro and difluoromethyl substituents, makes it a versatile building block for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the agrochemical and pharmaceutical industries seeking to introduce fluorinated motifs and heterocyclic scaffolds into new active ingredients.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel fungicides, herbicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in creating protease inhibitors and kinase inhibitors.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as ligands for catalysis or components for organic electronic devices.
• Custom Synthesis & Contract Manufacturing: Serves as a specialized starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	4-Chloro-1-(Difluoromethyl)-1H-Pyrazole-3-Carboxylic Acid
CAS No.	1310350-99-2
Molecular Formula	C5H3ClF2N2O2
Molecular Weight	196.54 g/mol
Synonyms	4-Chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid; 1H-Pyrazole-3-carboxylic acid, 4-chloro-1-(difluoromethyl)-; 4-Chloro-1-difluoromethyl-1H-pyrazole-3-carboxylic acid; 1310350-99-2; 4-Chloro-1-difluoromethylpyrazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA), including purity by HPLC, identity confirmation by NMR and IR, and impurity profile, is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.