Description

(2S)-3-[4-(tert-Butoxy)Phenyl]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2-Methylpropanoic Acid is a sophisticated, optically active amino acid derivative designed for advanced chemical synthesis. This compound is a critical building block in the development of complex molecules, offering a protected amino group and a chiral center for precise structural control. It is primarily utilized by researchers and process chemists in the pharmaceutical and biotechnology sectors for applications such as peptide synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: Serves as a key Fmoc-protected amino acid building block in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic compounds and active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Acts as a precursor for synthesizing labeled or modified peptides used in biochemical and cellular studies.
• Chiral Auxiliary/Resolution Agent: Utilized in asymmetric synthesis due to its defined stereochemistry at the 2-position.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific, protected amino acid motifs.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	(2S)-3-[4-(tert-Butoxy)Phenyl]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2-Methylpropanoic Acid
CAS No.	1309873-74-2
Molecular Formula	C29H31NO5
Molecular Weight	473.56 g/mol
Synonyms	Fmoc-(S)-3-(4-(tert-Butoxy)phenyl)-2-amino-2-methylpropanoic acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[4-(tert-butoxy)phenyl]-2-methylpropanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosine(2-methyl); Fmoc-O-tert-butyl-L-Tyr(2-Me)-OH; Fmoc-L-Tyr(2-Me, OtBu)-OH; N-α-Fmoc-O-tert-butyl-2-methyl-L-tyrosine; A protected 2-methyltyrosine derivative
EINECS	Contact for details

Quality Control

Our production of (2S)-3-[4-(tert-Butoxy)Phenyl]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2-Methylpropanoic Acid adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, enantiomeric excess, and impurity profiles to ensure batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.