Description

2,2-Difluoro-2-(2-Nitrophenyl)Acetic Acid is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a difluoroacetate moiety with a nitrophenyl group, enabling precise modifications in complex molecule construction. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals that require fluorinated aromatic components.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions and nucleophilic substitution reactions to introduce the difluoroacetic acid group.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new C-F bond formation methodologies and fluorophore development.
• Peptide Mimetic Design: Used to incorporate rigid, fluorinated motifs into peptide backbones to alter conformation and metabolic stability.

Basic Information

Product Name	2,2-Difluoro-2-(2-Nitrophenyl)Acetic Acid
CAS No.	1308915-13-0
Molecular Formula	C8H5F2NO4
Molecular Weight	217.13 g/mol
Synonyms	2-(2-Nitrophenyl)-2,2-difluoroacetic Acid; α,α-Difluoro-2-nitrobenzeneacetic Acid; 2-Nitro-α,α-difluorobenzeneacetic Acid; (2-Nitrophenyl)difluoroacetic Acid; Difluoro(2-nitrophenyl)acetic Acid; 2,2-Difluoro-2-(o-nitrophenyl)acetic Acid; DFNPA
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-(2-Nitrophenyl)Acetic Acid is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.