Description

(S,E)-Methyl 2-Amino-4-Phenylbut-3-Enoate Hydrochloride is a high-purity chiral building block and synthetic intermediate of significant value in modern organic synthesis. Its primary importance lies in its role as a key precursor for the development of novel pharmaceuticals, particularly in the synthesis of complex molecules with specific stereochemistry. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological and cardiovascular diseases.
• Peptidomimetics Research: Used in the design and construction of peptide analogs and mimetics for drug discovery programs.
• Asymmetric Synthesis: Serves as a versatile building block in catalytic asymmetric reactions to introduce chiral centers into complex molecular architectures.
• Agrochemical Development: Employed in the research phase for creating novel, enantiomerically pure crop protection agents and herbicides.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological pathways and mechanisms.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes conducting studies in synthetic methodology and medicinal chemistry.

Basic Information

Product Name	(S,E)-Methyl 2-Amino-4-Phenylbut-3-Enoate Hydrochloride
CAS No.	1308311-57-0
Molecular Formula	C11H14ClNO2
Molecular Weight	227.69 g/mol
Synonyms	Methyl (2S,3E)-2-amino-4-phenyl-3-butenoate hydrochloride; (S,E)-Methyl 2-amino-4-phenylbut-3-enoate HCl; (2S,3E)-2-Amino-4-phenyl-3-butenoic acid methyl ester hydrochloride; Methyl L-2-amino-4-phenyl-3-butenoate hydrochloride; (S)-Methyl 2-amino-4-phenylbut-3-enoate hydrochloride (E-isomer); 2-Amino-4-phenyl-3-butenoic acid methyl ester hydrochloride (S,E)-form
EINECS	Contact for details

Quality Control

Our (S,E)-Methyl 2-Amino-4-Phenylbut-3-Enoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.