Description

2-tert-Butyl-4,6-Dihydrospiro[Indazole-5,4-Piperidin]-7(2H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic indazole-piperidine structure. This compound is of significant value in medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D teams and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for creating new therapeutic agents targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Development & Scale-up: Serves as a critical material for developing and optimizing robust, scalable synthetic routes for API manufacturing.
• Biochemical Tool Compound: Potential use in biochemical assays and as a probe for investigating specific biological pathways and target interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.

Basic Information

Product Name	2-tert-Butyl-4,6-Dihydrospiro[Indazole-5,4-Piperidin]-7(2H)-One
CAS No.	1307381-60-7
Molecular Formula	C15H21N3O
Molecular Weight	259.35 g/mol
Synonyms	2-tert-Butyl-4,6-dihydro-2H-spiro[indazole-5,4'-piperidin]-7(6H)-one; 2-(tert-Butyl)-4,6-dihydrospiro[indazole-5,4-piperidine]-7(2H)-one; 2-tert-Butyl-2,4,6,7-tetrahydrospiro[indazole-5,4'-piperidin]-7-one; Spiro[indazole-5,4'-piperidine]-7(2H)-one, 2-(1,1-dimethylethyl)-4,6-dihydro-; 1307381-60-7; 2-tert-Butyl-4,6-dihydro-2H-spiro[indazole-5,4'-piperidin]-7-one
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl-4,6-Dihydrospiro[Indazole-5,4-Piperidin]-7(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and regulatory compliance ensures a reliable supply for demanding pharmaceutical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.