Description

tert-Butyl2'-Chloro-4',4'-Difluoro-4',5'-Dihydrospiro[Piperidine-4,7'-Thieno[2,3-C]Pyran]-1-Carboxylate is a high-value, complex spirocyclic organic intermediate with significant utility in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring a fused thienopyran and piperidine ring system, makes it a critical building block for synthesizing novel bioactive compounds. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating potential new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the design and construction of molecular probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): A critical material for organizations providing custom synthesis and development services to the global pharma industry.

Basic Information

Product Name	tert-Butyl2'-Chloro-4',4'-Difluoro-4',5'-Dihydrospiro[Piperidine-4,7'-Thieno[2,3-C]Pyran]-1-Carboxylate
CAS No.	1307248-48-1
Molecular Formula	C16H20ClF2NO3S
Molecular Weight	379.85 g/mol
Synonyms	1-Boc-2'-Chloro-4',4'-difluoro-1',4'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]; tert-Butyl 2'-chloro-4',4'-difluoro-1',4'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-carboxylate; Spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',4'-difluoro-1',4'-dihydro-, 1,1-dimethylethyl ester; 1307248-48-1; 1,1-Dimethylethyl 2'-chloro-4',4'-difluoro-1',4'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-carboxylate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems to ensure consistency and reliability for critical R&D applications. Our standard offering meets a typical purity specification of ≥95% (by HPLC), with higher purity grades available upon request. Comprehensive analytical characterization, including HPLC, NMR, and MS, is performed to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.