Description

Dichloro[1,3-Bis(2,6-Diisopropylphenyl)-2-Imidazolidinylidene](3-Phenyl-1H-Inden-1-Ylidene)(Triphenylphosphine)Ruthenium(II) is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound matters for its exceptional thermal stability and functional group tolerance, enabling complex organic transformations in demanding synthetic sequences. It is critically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient construction of carbon-carbon double bonds.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for ring-closing metathesis (RCM) and cross-metathesis (CM) in the production of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific olefin architectures.
• Polymer & Material Science: Enables the synthesis of specialty polymers via acyclic diene metathesis (ADMET) polymerization and the creation of functionalized materials.
• Fine Chemical Production: Facilitates efficient, scalable routes to fragrances, flavors, and other high-value specialty chemicals.
• Academic & Industrial R&D: A premium tool for methodological development and exploring new chemical space in catalysis and synthetic chemistry.
• Cross-Coupling & Tandem Catalysis: Can be employed in sequential or tandem catalytic processes alongside other transition metal catalysts.

Basic Information

Product Name	Dichloro[1,3-Bis(2,6-Diisopropylphenyl)-2-Imidazolidinylidene](3-Phenyl-1H-Inden-1-Ylidene)(Triphenylphosphine)Ruthenium(II)
CAS No.	1307233-23-3
Molecular Formula	C59H66Cl2N2PRu
Molecular Weight	1000.06 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation, Indenylidene Version; Hoveyda-Grubbs Catalyst 2nd Gen; (1,3-Bis(2,6-Diisopropylphenyl)-2-imidazolidinylidene)dichloro(3-phenyl-1H-inden-1-ylidene)(triphenylphosphine)ruthenium(II); Zhan Catalyst 1B; Ru-Indenylidene NHC Catalyst; Dichloro(o-isopropoxyphenylmethylene)(triphenylphosphine)ruthenium(II) derivative; [RuCl2(IMesH2)(Ind)(PPh3)]
EINECS	Contact for details

Quality Control

Every batch of our ruthenium metathesis catalysts is produced and tested under strict inert atmosphere conditions to ensure activity and purity. We provide comprehensive Certificates of Analysis (COA) detailing key performance indicators such as catalytic activity and impurity profiles. Our quality systems are designed to support cGMP and ISO 9001 compliant manufacturing for our partners in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, freezer. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade catalyst performance.

Specification

Item	Specification
Appearance	Dark purple to brown crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chlorinated solvents, toluene, THF
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.