Description

(S)-1-Amino-2,3-Dihydro-1H-Indene-4-Carbonitrile Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. Its rigid indane scaffold and functionalized amine and nitrile groups make it a versatile precursor for constructing complex bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for applications requiring enantiomerically pure intermediates in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Serves as a starting material or precursor in asymmetric catalytic reactions to introduce stereogenic centers into target molecules.
• Ligand and Catalyst Development: Used in the research and development of novel chiral ligands and organocatalysts for stereoselective transformations.
• Agrochemical Research: Employed as a building block in the discovery and synthesis of new, enantiomerically pure pesticides and herbicides.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science: Potential precursor for the synthesis of specialty polymers or advanced organic materials with specific chiral properties.

Basic Information

Product Name	(S)-1-Amino-2,3-Dihydro-1H-Indene-4-Carbonitrile Hydrochloride
CAS No.	1306763-57-4
Molecular Formula	C10H11N2•HCl
Molecular Weight	194.67 (Free base), 231.09 (Hydrochloride salt)
Synonyms	(S)-1-Amino-4-cyano-2,3-dihydro-1H-indene hydrochloride; (S)-4-Cyano-2,3-dihydro-1H-inden-1-amine hydrochloride; (S)-1-Aminoindane-4-carbonitrile hydrochloride; (1S)-1-Amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride; (S)-Aminoinndan-4-carbonitril hydrochloride; (S)-1-Amino-4-cyanoindane HCl; 1306763-57-4
EINECS	Contact for details

Quality Control

Our (S)-1-Amino-2,3-Dihydro-1H-Indene-4-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.