Description

(E)-tert-Butyl 5-(3-Methoxy-3-Oxoprop-1-En-1-Yl)-1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is a critical building block valued for its defined stereochemistry and functional groups that enable efficient downstream chemical transformations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially kinase inhibitors.
• Organic Synthesis Building Block: Used in cross-coupling reactions, such as Suzuki or Heck couplings, to construct complex heterocyclic scaffolds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for scale-up synthesis under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological development and the exploration of new chemical entities.
• Bioconjugation Chemistry: The activated ester moiety can be leveraged for conjugation with biomolecules in probe or prodrug development.

Basic Information

Product Name	(E)-tert-Butyl 5-(3-Methoxy-3-Oxoprop-1-En-1-Yl)-1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate
CAS No.	1305332-66-4
Molecular Formula	C16H19N3O4
Molecular Weight	317.34 g/mol
Synonyms	tert-Butyl (E)-5-(3-methoxy-3-oxoprop-1-en-1-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 1H-Pyrazolo[3,4-b]pyridine-1-carboxylic acid, 5-(3-methoxy-1-oxo-2-propen-1-yl)-, 1,1-dimethylethyl ester, (E)-; 1-(tert-Butoxycarbonyl)-5-[(E)-3-methoxy-3-oxoprop-1-en-1-yl]-1H-pyrazolo[3,4-b]pyridine; Boc-Protected Pyrazolopyridine Acrylate Ester; (E)-1-Boc-5-(3-Methoxy-3-oxoprop-1-enyl)pyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our production of (E)-tert-Butyl 5-(3-Methoxy-3-Oxoprop-1-En-1-Yl)-1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.