Description

4-Bromo-2-(tert-Butyl)-6-Iodo-7-(Trimethylsilyl)-Oxazolo[4,5-C]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound is engineered to serve as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and functional materials, offering unique reactivity from its halogen and silyl substituents. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors or other heterocycle-based therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the oxazolopyridine core can contribute to novel modes of action.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) or semiconductors, due to its conjugated system and functional handles.
• Cross-Coupling Reactions: The bromo and iodo groups are excellent substrates for versatile metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Negishi) to create complex biaryl structures.
• Functional Group Transformation: The trimethylsilyl group can be used as a protective group or selectively modified, offering a strategic point for further synthetic elaboration.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	4-Bromo-2-(tert-Butyl)-6-Iodo-7-(Trimethylsilyl)-Oxazolo[4,5-C]Pyridine
CAS No.	1305324-93-9
Molecular Formula	C14H20BrIN2OSi
Molecular Weight	467.22 g/mol
Synonyms	4-Bromo-2-tert-butyl-6-iodo-7-(trimethylsilyl)oxazolo[4,5-c]pyridine; 7-(Trimethylsilyl)-4-bromo-2-(tert-butyl)-6-iodooxazolo[4,5-c]pyridine; Oxazolo[4,5-c]pyridine, 4-bromo-2-(1,1-dimethylethyl)-6-iodo-7-(trimethylsilyl)-; 4-Bromo-2-(tert-butyl)-6-iodo-7-(trimethylsilyl)-[1,3]oxazolo[4,5-c]pyridine; 1305324-93-9
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(tert-Butyl)-6-Iodo-7-(Trimethylsilyl)-Oxazolo[4,5-C]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.