Description

1-(4-Chloro-2-Fluorophenyl)Propan-2-One is a versatile and high-purity fluorinated aromatic ketone intermediate. This compound is critical for the synthesis of advanced pharmaceutical molecules and complex agrochemicals, offering a precise structural motif for further functionalization. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable building blocks for novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the chloro-fluoro substitution pattern enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of novel organic electronic materials and liquid crystals due to its specific aromatic and halogenated structure.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	1-(4-Chloro-2-Fluorophenyl)Propan-2-One
CAS No.	1305324-05-3
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	2-Propanone, 1-(4-chloro-2-fluorophenyl)-; 4'-Chloro-2'-fluoroacetophenone; 1-(4-Chloro-2-fluorophenyl)ethanone; 2-Fluoro-4-chloroacetophenone; p-Chloro-o-fluoroacetophenone; 4-Chloro-2-fluoroacetophenone; 1-Acetyl-4-chloro-2-fluorobenzene; 1305324-05-3
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-2-Fluorophenyl)Propan-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant global regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.